Altered T Lymphocyte Proliferation upon Lipopolysaccharide Challenge Ex Vivo

Altered T Lymphocyte Proliferation upon Lipopolysaccharide Challenge Ex Vivo.

CONTEXT Sepsis is characterized by the development of adaptive immune cell alterations, which intensity and duration are associated with increased risk of health-care associated infections and mortality. However, pathophysiological mechanisms leading to such lymphocyte dysfunctions are not completely understood, although both intrinsic lymphocyte alterations and antigen-presenting cells (APCs) ...

Gene Expression upon Proliferation and Differentiation of Hematopoietic Cells with Ph Chromosome ex vivo

The genesp53, mdm2, p21, c-myc,bcr/abl, bcr, bcl2, bax, and gapdh participate in the regulation of cell proliferation and differentiation, apoptosis and cell distribution for the cell cycle ex vivo in the Ph(+)cells of chronic myeloid leukemia containing the Ph chromosome andbcr/abloncogene. Expression of these genes correlates with regulation of cell proliferation and differentiation by altern...

Fatty acid inhibition of lipopolysaccharide-stimulated B lymphocyte proliferation.

We have recently shown that saturated, monounsaturated and polyunsaturated fatty acids, including those of fish-oil origin, inhibit [ 'Hlthymidine incorporation into DNA of concanavalin A (Con A)-stimulated rat lymph node lymphocytes [ 1, 21. All nine fatty acids tested inhibited the response to mitogen, but the extent of inhibition was dependent upon the fatty acid concentration used, the time...

Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo

Antigen priming of naive CD4 T cells can generate effector CD4 T cells that produce interleukin 4 (T helper [Th]2-like) or interferon-gamma (Th1-like). Using a system in which priming leads to responses dominated by one or the other of these cell types, we show that varying either the antigenic peptide or the major histocompatibility complex class II molecule can determine whether Th1-like or T...

Ex Vivo Cytokine and Memory T Cell